Dapsone Hypersensitivity Syndrome- A Fatal Adverse Drug Reaction
نویسندگان
چکیده
منابع مشابه
Severe dapsone hypersensitivity syndrome.
Dapsone, a potent antiparasitic and anti-inflammatory compound, is mainly used in the treatment of leprosy and a variety of blistering skin diseases. It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome. We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome. The clinical presentation mimicked a vir...
متن کاملDapsone hypersensitivity syndrome with myocarditis.
Drug hypersensitivity with myocarditis is known to occur with many drugs especially with antiepileptics, sulpha-compounds and daposne. Dapsone (4, 4 diaminodiphenyl sulphone) induced hypersensitivity is known to occur in about 2% of leprosy patients on treatment and an incidence of 1.66% in non-leprosy patients. We report this rare case of dapsone hypersensitivity syndrome in a girl on dapsone ...
متن کاملSevere dapsone hypersensitivity syndrome in a child
Dapsone (4,4'-diaminodiphenylsulfone, DDS), a potent anti-inflammatory agent, is widely used in the treatment of leprosy and several chronic inflammatory skin diseases. Dapsone therapy rarely results in development of dapsone hypersensitivity syndrome, which is characterized by fever, hepatitis, generalized exfoliative dermatitis, and lymphadenopathy. Here, we describe the case of an 11-year-ol...
متن کاملHypersensitivity reaction to dapsone: report from Malaysia.
Three patients who developed hypersensitivity reaction at varying intervals after the initiation of dapsone therapy are described. Two of them had leprosy whereas the other had dermatitis herpetiformis. Their clinical manifes tations were not uniform. Although fatal complications have been reported, the unique role played by dapsone in the treatment of leprosy and the importance of recognizing...
متن کاملAllopurinol hypersensitivity syndrome: a preventable severe cutaneous adverse reaction?
INTRODUCTION Allopurinol is a widely-prescribed urate-lowering agent. Allopurinol hypersensitivity syndrome, a severe form of cutaneous adverse reaction, is associated with significant mortality and morbidity. The aim of this study was to document the clinical presentation of allopurinol hypersensitivity in a local population, examine the indications for urate-lowering therapy and to identify p...
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ژورنال
عنوان ژورنال: Internal Medicine: Open Access
سال: 2011
ISSN: 2165-8048
DOI: 10.4172/2165-8048.1000123